Prof. J. C. Philip, O.B.E., F.R.S

Philip J. Fay (1953-2014).

Philip J. Fay, Ph.D., Professor of Biochemistry and Biophysics at the University of Rochester, passed away on June 25, 2014 at the age of 61. He succumbed to the multiple myeloma that he had battled valiantly for 6 years. Phil is survived by his wife of 38 years, Andrea, daughters Amber and Emily, and five grandchildren. On July 8th the flags at the University of Rochester were lowered in his h...

By Philip J . Morrissey , David Bradley

Self-recognition and self-tolerance are two characteristics of the receptor repertoire expressed by functionally reactive T cells. Both of these facets of the T cell receptor repertoire are importantly influenced by the environment in which immature T cell precursors differentiate. For example, T cells specifically recognize as self the major histocompatibility complex (MHC)l-encoded determinan...

By Stanley J . Korsmeyer , Philip a . Hieter ,

The maturation of a pre-B cell to an immunoglobulin (Ig)-bearing B cell requires an effective recombination of a light chain variable (VL) 1 and joining (JL) gene segment (1-11). Man uses both light chain gene classes appreciably, expressing K light chain in -60% and ~ light chain in 40% of mature B cells. Despite their nearly equal usage, however, the rearrangement of human Ig light chain gene...

Prof. Dr. Prof. Prof.

OBE: Outlier by Example

Outlier detection in large datasets is an important problem. There are several recent approaches that employ very reasonable definitions of an outlier. However, a fundamental issue is that the notion of which objects are outliers typically varies between users or, even, datasets. In this paper, we present a novel solution to this problem, by bringing users into the loop. Our OBE (Outlier By Exa...